AB0351 PROGRESSION TO SEVERE LUPUS NEPHRITIS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOUS: UPDATE FROM A COLOMBIAN COHORT

Background: Continuous monitoring of patients with Systemic lupus erythematosus (SLE) provides relevant information Objectives: To update the analysis clinical and immunological characteristics associated time to severe renal involvement in Lupus Erythematous a Colombian cohort followed from January 2015 October 2020 Methods: A retrospective follow-up study based on records. Patients SLE diagnosis fulfilled either 1987 American College Rheumatology Classification Criteria for or 2011 International Collaborating Clinics (SLICC) classification criteria SLE. We included nephritis according Wallace Dubois criteria. who did not have at least two measurements had cause other than were excluded. The primary outcome was defined as creatinine clearance ≤50ml/min, 24-hour proteinuria ≥3.5 grams o end-stage disease. Updated age sex-adjusted survival functions Hazard ratios (HR) 95% confidence intervals p-values estimated using parametric Weibull models interval-censored data. P values <0.05 considered statistically significant. Descriptive statistics previously reported EULAR (1) Results: 548 analyzed: 67 left-censored they presented entry, 25 interval censored occurred between visits (19 new events), 456 right-censored registered during follow-up. In this Age Ratios high blood pressure HR = 3.1 (95%CI 1.5-6.3; p-value 0.003) Anti-RO (per unit increase) 1.003 1.001-1.005; 0.029). Figure 1 shows updated function Conclusion: update, we found similar those (1). However, continuous allows us deepen our understanding progression References: [1]Herrera S, Diaz-Coronado JC, Rojas-Gualdrón D, Betancur-Vasquez L, Gonzalez-Hurtado Gonzalez-Arango J, et al. SAT0210 factors colombian patients. Ann Rheum Dis. junio de 2020;79(Suppl 1):1048.2-1048 Disclosure Interests: None declared